Can a single diet cure depression, lower cholesterol and help you live longer?
As the saying goes, everything old is new again. The Mediterranean diet, with its focus on plant foods, fish and olive oil, hit the headlines a couple of decades ago when studies found that countries like Italy, Spain and Greece had a lower incidence of heart disease, compared to their northern European neighbours.
While many popular diets are just fads, the Mediterranean diet may be the only one that has lasted. Ongoing research has linked it to a longer life expectancy, as well as decreasing the risk of Parkinson’s, Alzheimer’s some cancers and other chronic diseases.
In 2016 prevention and treatment of two further health conditions were added to the diet’s success story – reducing cardiovascular risks and depression.
The preliminary findings of a cardiovascular study triggered worldwide headlines claiming that the Mediterranean diet is “more effective in lowering cholesterol, than statin drugs”.
The study included 1,200 older people with a history of blocked arteries, stroke or heart attacks who were placed on the Mediterranean diet. While the research is yet to be published, its conclusions reinforce the positive impact of plant-focused diet on cholesterol levels and add to the increasing controversy around statins.
The second study, from Deakin University, used a version of the Mediterranean diet to reduce major depression symptoms. Though there are some limitations to the Deakin study, it reinforces a long-held naturopathic belief that a plant and fish based diet plays an important role in maintaining good mental health.
What is the Mediterranean diet?
The version of the Mediterranean diet used by most researchers is based around eating a lot of olive oil, nuts, vegetables, fresh fruits and whole grains, with a moderate amount of fish and poultry, sheep or goats milk yoghurt/cheese. Red meat is eaten occasionally, while processed meats and sweets are avoided.
Traditionally in Mediterranean countries, locally grown food is bought fresh each day and cooked from scratch. Wild fish is caught daily and often cooked (grilled or baked) whole. This wouldn’t include farmed fish like Atlantic salmon and barramundi. The wine that people consume in these regions is usually young, local red wine, which is high in antioxidants and drunk “in moderation”.
Village life is traditionally very physically active. It’s well known that cardiovascular health can’t rely on good food alone and exercise is vital.
How to eat an ideal Mediterranean diet
Focus on eating mostly the foods on the bottom layer of the Mayo clinic Mediterranean diet pyramid and try the following tips:
- If you can’t shop every day, try to buy fresh fish and vegetables three times a week.
- Have canned beans and tomatoes on hand to make quick vegetarian dishes.
- Eat more raw, unsalted nuts. Try adding them to your breakfast and salads.
- Use fresh herbs and spices, rather than salt, to improve the flavour of your food.
- When eating out, consider a shared traditional Greek/Spanish/Italian style of meal of fresh fish with a variety of vegetable side dishes. Skip dessert.
- Drink 6 to 8 glasses of water a day. Avoid soft drinks and juices.
- If you’re not intolerant to dairy, limit it to a little unsweetened sheep’s yoghurt and sheep or goat’s cheese.
- If you drink alcohol, have one glass of wine with meals (instead of before, after or instead of eating). Note: there’s increasing evidence that drinking alcohol (in any amount) increases a woman’s risk of developing breast cancer.

A simple meal at a Greek taverna might include freshly caught fish straight off the grill, with salad or a plate of greens or beans.
Criticisms of the Mediterranean diet studies
Perhaps a better name for the diet used by researchers is the ideal Mediterranean diet. It harks back to the days of village life and doesn’t necessarily reflect the way people from these cultures currently eat. The diet adopted for most of the studies often exclude some foods that are frequently eaten foods in the Mediterranean region. For example, processed grains (flour) are usually absent from the guidelines, yet white bread (and pasta) is a staple in these countries.
The Deakin depression study selectively recruited participants who had a pre-existing “poor” diet, excluding those who already ate a reasonable diet. The direct impact of the Mediterranean diet on mental health, rather than the mere exclusion of ‘unhealthy’ foods, is unknown.
Often people experiencing a severe depressive episode can lack motivation to shop, cook and generally eat well. It would be interesting to see if support for long-term diet change can lower the frequency or severity of depressive episodes.
Deakin University researchers created their own version of the Mediterranean diet which they call the “ModiMedDiet”. Unlike previous studies, for example the Mayo Clinic model, this diet controversially includes three to four serves of red meat a week. The Deakin study acknowledges that the Meat and Livestock Association financially contributed to their research and has also provided other grants to the key author. While their research is still promising, this is a significant variation in the base diet used in other Mediterranean diet studies.
A diet or a lifestyle?
There are many healthy aspects to an ideal Mediterranean way of life. A plant-based diet with a liberal addition of seafood, regular physical activity and sunshine are all factors that can contribute to good mental and physical health.
While some aspects of the Mediterranean diet remain controversial, such as the inclusion of flour and red meat, the evidence is conclusive that a wide-variety of unrefined plant foods provides a keystone for healthy eating.
Update March 2017: a study of over 62,000 women aged 55 – 69 found they had a 40% reduced risk of developing one type of breast cancer. The women followed a Mediterranean diet that had been altered to exclude alcohol (a known breast cancer risk). There were fewer cases of oestrogen receptor negative cancers, a type of breast cancer that responds poorly to conventional treatment.
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Here in the USA we have many doctors and nutritionists recommending a very low fat whole food plant-based diet. The research for this by Dr. Dean Ornish, Dr. Caldwell Esselstyn and Dr. Mc. Dougall was enough to convince me to become vegan 5 years ago at age 75. I had been vegetarian for 25 years but the research on the cardiovascular benefits of a vegan diet were so compelling. (I hiked to the bottom of the Grand Canyon and back on my 80th birthday so I guess my heart is still OK.
All the above doctors consider the main benefits of the Mediterranean Diet come from increased consumption of fruits and vegetables and consider a low fay vegan diet even more efficacious.
Hi Alan,
Congrats on your Grand Canyon hike! What a wonderful way to celebrate your 80th birthday.
I think fat is the most contentious diet/health issues of our time. Liberal use of olive oil (especially raw, on salads etc) is a cornerstone of all the variations of the Mediterranean diet. I’m not aware of any compelling research into ‘low fat’ versions of the diet.
I personally believe there are many therapeutic benefits from regularly eating cold pressed/or foods containing plant and fish oils. But there’s no one diet that suits everyone’s body. The role of animal fat and the fact that it’s almost always been heated, is hotly debated. In Australia, as I noted in one of the studies, the Meat and Livestock lobby regularly contributes money to diet based medical research, as well as sponsoring medical and health groups. I don’t think the impact of this conflicting interest is being discussed enough (or at all, especially in the mainstream media).
You might like some of my recipes in my resources section, most are vegan and all are delicious!